Developmental regulation of granulocyte-macrophage colony-stimulating factor production during human monocyte-to-macrophage maturation
β Scribed by S. W. Krause; M. Kreutz; G. Zenke; R. Andreesen
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 931 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0939-5555
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Combinations of low dosages of purified recombinant human (rh) macrophagecolony stimulating factor (M-CSF; also termed CSF-1) and rh granulocyte-colony stimulating factor (G-CSF) were compared alone and in combination for their influence on the cycling rates and numbers of bone marrow and splenic gr
## Abstract Colonyβstimulating factor (CSF) is necessary for the clonal growth of human bone marrow in vitro. Human blood monocytes and macrophages produce CSF. Endotoxin was found to increase the level of CSF generated by macrophages, but had no stimulatory effect on monocytes. Several other subst