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Effect of endotoxin on the production of colony-stimulating factor by human monocytes and macrophages

✍ Scribed by Martin J. Cline; Belina Rothman; David W. Golde

Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
313 KB
Volume
84
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Colony‐stimulating factor (CSF) is necessary for the clonal growth of human bone marrow in vitro. Human blood monocytes and macrophages produce CSF. Endotoxin was found to increase the level of CSF generated by macrophages, but had no stimulatory effect on monocytes. Several other substances known to influence the pinocytic or phagocytic activity of mononuclear phagocytes failed to enhance cellular CSF generation.

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