Transfection of mutantp53gene depresses X-ray- or CDDP-induced apoptosis in a human squamous cell carcinoma of the head and neck
β Scribed by K. Ohnishi; I. Ota; A. Takahashi; K. Yane; H. Matsumoto; T. Ohnishi
- Book ID
- 110345834
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 387 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1360-8185
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π SIMILAR VOLUMES
Abnormalities in the p53 gene were studied in a series of cell lines of human squamous-cell carcinoma of the head and neck (SCCHN) and in tumor tissues. Restriction-fragment-length polymorphism (RFLP), quantitative hybridization and immunochemical analysis of mutant p53 proteins were combined to det
## Abstract ## Background Human papillomavirus (HPV)βpositive cases of squamous cell carcinoma of the head and neck (SCCHN) have a much better disease outcome compared to SCCHN cases lacking HPV. Differences in microRNA (miRNA) expression may affect their clinical outcomes. ## Methods The miRNA