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Transesterification-based enzymatic resolutions of racemic 3-hydroxy-4-pentenylurethanes in organic solvents

✍ Scribed by Hiroki Takahata; Yasuhiro Uchida; Takefumi Momose


Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
165 KB
Volume
33
Category
Article
ISSN
0040-4039

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✦ Synopsis


An expedient synthesis of homochiral N-protected (R)and (S)-3-hydroxy+pentenylamines (1 and 2) has been accomplished via the enzymatic resolution of the racemic 1 and 2 mediated by immobilized lipase in pcntane.


πŸ“œ SIMILAR VOLUMES


Enzymes in Organic Synthesis, 8. Synthes
✍ Weidner, Judith ;Theil, Fritz ;Kunath, Annamarie ;Schick, Hans πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 271 KB

## Abstract Lipase Amano PS is a suitable biocatalyst for the highly regio‐ and enantioselective transesterification of the racemic prostaglandin building block (1__S__~\*~,5__R__\*,6__R__\*,7__R__\*)‐(Β±)‐7‐hydroxy‐6‐hydroxymethyl‐2‐oxabicyclo[3.3.0]octan‐3‐one (__rac__‐1) yielding (1__S__,5__R__,6