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Enzymatic resolution of racemic amines in a continuous reactor in organic solvents

✍ Scribed by Arie L. Gutman; Elazar Meyer; Evgeny Kalerin; Felix Polyak; Jeffrey Sterling

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
850 KB
Volume
40
Category
Article
ISSN
0006-3592

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A trapped aqueous-organic biphase system for the continuous production of (S)-(+)-2-(6-methoxy-2-naphthyl) propionic acid (Naproxen) has been developed. The process consists of a stereoselective hydrolysis of the racemic Naproxen methyl ester by Candida rugosa lipase in a trapped aqueous-organic bip