Transcriptional repression of tissue inhibitor of metalloproteinase-3 by Epstein-Barr virus latent membrane protein 1 enhances invasiveness of nasopharyngeal carcinoma cells
✍ Scribed by Shu-Hui Chang; Hui-Chiu Chang; Wen-Chun Hung
- Book ID
- 113832971
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 471 KB
- Volume
- 44
- Category
- Article
- ISSN
- 1368-8375
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## Abstract ## Background Nasopharyngeal carcinoma (NPC) is associated with Epstein–Barr virus (EBV) infection. We previously found that interleukin (IL)‐1α and IL‐1β significantly increased in NPC tissues. This study investigated what EBV‐encoded proteins were involved in such IL‐1 production. #
## Abstract Nasopharyngeal carcinoma is closely associated with Epstein‐Barr virus (EBV) and the EBV encoded latent membrane protein‐1 expression (LMP1) is commonly found in the tumour cells. LMP1 has been shown to be involved in modulation of cell growth in B cells but the biological properties of