Transcriptional Control of Left–Right Patterning in Cardiac Development
✍ Scribed by Chiann-mun Chen; Dominic Norris; Shoumo Bhattacharya
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 252 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0172-0643
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Left±right asymmetric signaling molecules in mammals include three transforming growth factor b (TGFb)-related factors, Nodal, Lefty1 and Lefty2. They are all expressed on the left half of developing mouse embryos. Nodal acts as a left-side determinant by transducing signals through Smad and FAST an
## Abstract A central problem in neurobiology is the elucidation of the mechanisms that underlie left–right asymmetries in brain structure and function. Using a transcriptome screening approach, we found asymmetric gene expression patterns in the right when compared with the left hippocampal format