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Classification of left-right patterning defects in zebrafish, mice, and humans

✍ Scribed by Bisgrove, Brent W. ;Yost, H. Joseph

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
151 KB
Volume
101
Category
Article
ISSN
0148-7299

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LeftΒ±right asymmetric signaling molecules in mammals include three transforming growth factor b (TGFb)-related factors, Nodal, Lefty1 and Lefty2. They are all expressed on the left half of developing mouse embryos. Nodal acts as a left-side determinant by transducing signals through Smad and FAST an