Fluid dynamics of nodal flow and left–right patterning in development
✍ Scribed by Julyan H.E. Cartwright; Nicolas Piro; Oreste Piro; Idan Tuval
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 944 KB
- Volume
- 237
- Category
- Article
- ISSN
- 1058-8388
No coin nor oath required. For personal study only.
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Left±right asymmetric signaling molecules in mammals include three transforming growth factor b (TGFb)-related factors, Nodal, Lefty1 and Lefty2. They are all expressed on the left half of developing mouse embryos. Nodal acts as a left-side determinant by transducing signals through Smad and FAST an
## Abstract A central problem in neurobiology is the elucidation of the mechanisms that underlie left–right asymmetries in brain structure and function. Using a transcriptome screening approach, we found asymmetric gene expression patterns in the right when compared with the left hippocampal format