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Transcriptional and post-translational regulation of mouse cation transport regulator homolog 1

✍ Scribed by Kentaro Oh-hashi, Yuki Nomura, Kiyo Shimada…

Book ID
120748610
Publisher
Springer
Year
2013
Tongue
English
Weight
444 KB
Volume
380
Category
Article
ISSN
0300-8177

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## Abstract PTEN is a critical tumor suppressor gene mutated frequently in various human cancers. Previous studies have showed that PTEN mRNA expression is down‐regulated by TGF‐β1 in various cell lines. In present study, we have found that TGF‐β1 down‐regulates PTEN mRNA and protein expression in