Transcriptional Activators of TGF-β Responses: Smads
✍ Scribed by Rik Derynck; Ying Zhang; Xin-Hua Feng
- Book ID
- 117268450
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 110 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0092-8674
No coin nor oath required. For personal study only.
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TGFbeta inducible early gene (TIEG) is a novel Krüppel-like transcriptional repressor that was recently shown to increase the activity of the TGFbeta/Smad signal transduction pathway by relieving negative feedback through repression of the inhibitory Smad7. Interestingly, while Smad7 is required for
## Abstract Furin is recognized as being one of the main convertases of the cellular constitutive secretion pathway but the mechanisms regulating its expression are still unknown. We have previously demonstrated that TGFβ1 up‐regulates its own converting enzyme, furin, creating a novel activation/r