Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-β/Smad3-mediated transcriptional activation
✍ Scribed by Cheng, Pei-Lin; Chang, Meng-Hsiung; Chao, Chi-Hong; Lee, Yan-Hwa Wu
- Book ID
- 110069131
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 800 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0950-9232
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Transcription of the alpha2(I) collagen gene (COL1A2) in fibroblasts is potently induced by transforming growth factor-beta (TGF-beta). Smad family proteins function as intracellular signal transducers for TGF-beta that convey information from the cell membrane to the nucleus. In the present study,