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Transcriptional activation of the senescence regulator Lsh by E2F1

✍ Scribed by Jing Niu; Tianda Chen; Limin Han; Pan Wang; Na Li; Tanjun Tong


Book ID
113776353
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
543 KB
Volume
132
Category
Article
ISSN
0047-6374

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Cellular transcription factor E2F1 is thought to regulate the expression of genes important for cell cycle progression and cell proliferation. Deregulated E2F1 expression induces S-phase entry in quiescent cells and inhibits myogenic differentiation. We show here that E2F1 inhibits the activation of