✦ LIBER ✦

trans N-Methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] cycloprop-2-ene-1-carboxamides: Novel lipophilic kappa opioid agonists

✍ Scribed by V. Sabin; D.C. Horwell; A.T. McKnight; P. Broqua

Book ID: 104364758
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 236 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00615-4

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✦ Synopsis

The synthesis and kappa opioid agonist activities of some lipophilic analogues of the kappa opioid agonist U-50488 incorporating motifs bearing two aromatic rings in place of the 3,4dichlorophenyl group are described.

1-carboxamide, 13, is a highly lipophilic chemically novel potent selective kappa opioid agonist.

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