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Naphtho and benzo analogs of the .kappa. opioid agonist trans-(.+-.)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide

✍ Scribed by Freeman, Jeremiah P.; Michalson, Eric T.; D'Andrea, Stan V.; Baczynskyj, Lubomir; VonVoigtlander, Philip F.; Lahti, R. A.; Smith, Martin W.; Lawson, Charles F.; Scahill, Terrence A.


Book ID
120033478
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
741 KB
Volume
34
Category
Article
ISSN
0022-2623

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Synthesis of high specific activity trit
✍ Brian R. De Costa; Andew Thurkauf; Richard R. Rothman; Arthur E. Jacobson; Kenne πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 French βš– 383 KB

## Abstract Optically pure tritium labeled 1__S__,2__S__‐(‐)‐__trans__‐2‐isothiocyanato‐N‐methyl‐N‐[2‐(1‐pyrrolidinyl)cyclohexyl]benzeneacetamide, an affinity ligand specific for the kappa opioid receptor was synthesized from optically pure 1__S__,2__S__‐(‐)‐__trans__‐2‐amino‐N‐methyl‐N‐[2‐(1‐pyrro