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TPM: a new protecting group for alkynes

โœ Scribed by Ariel Haskel; Ehud Keinan

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
319 KB
Volume
40
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A new alkyne protecting group, trispyrazolylborateplatinum(methyl) (TPM), that can tolerate various reaction conditions and is particularly useful for electron-deficient acetylenes allows for synthetic manipulations of polyfunctional acetylenes. This protecting group withstands a variety of reaction conditions, including basic and acidic media, and the environment required for catalytic hydrogenation and for chromate oxidation reaction. The alkyne product is conveniently released from the protecting complex by the use of carbon monoxide under neutral conditions and ambient temperatures.

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