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Toxicity of Methoxyacetic Acid in Rats

โœ Scribed by MILLER, R.R.; CARREON, R.E.; YOUNG, J.T.; McKENNA, M.J.


Book ID
125534935
Publisher
Oxford University Press
Year
1982
Tongue
English
Weight
277 KB
Volume
2
Category
Article
ISSN
1096-6080

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The ethylene glycol ether 2-methoxyethanol (ME) and its oxidation product methoxyacetic acid (MAA) are selective embryotoxins and equipotent as inducers of digit malformations when given by gavage to pregnant Cr1:CD-1 ICR BR mice on gestation day 11. Earlier observations showed that the teratogenic