Toxicity of hexachlorocyclopentadiene: Subchronic (13-week) administration by gavage to F344 rats and B6C3F1, mice

✍ Scribed by K. M. Abdo; C. A. Montgomery; W. M. Kluwe; D. R. Farnell; J. D. Prejean

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 703 KB
• Volume: 4
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550040204

✦ Synopsis

A 13-week subchronic study was conducted by administering hexachlorocyclopentadiene (HCCP) in corn oil by gavage to groups of ten male and ten female F344 rats at doses of 150,75,38,19,10 or 0 mg kg-', and to groups of ten male and ten female B6C3F1 mice at doses of 300, 150, 75, 38, 19 or 0 mg kg-'. The doses were administered once a day, five days per week for 13 weeks. Chemically induced deaths occurred at 150 and 300 mg kg-' in rats and at 300 mg kg-' in mice. A significant (P <0.05) depression in mean body-weight change relative to controls was observed in male and female rats receiving 2 38 and 2 75 mg kg-', respectively, and in male and female mice receiving 150 and 300 mg kg-', respectively. There was a significant (P<0.05) increase in liver and kidney weight: brain weight ratios in the highdose female rats (75 and 150 mg kg-') and female mice at all doses (19-300 mg kg-'). HCCP caused proliferative and inflammatory changes of the epithelia in the forestomach of male rats, and male and female mice receiving 2 38 mg kg-' and in female rats receiving 2 1 9 mg kg dose level. Nephrosis characterized by proximal tubular dilation, cytoplasmic vacuolization, cytomegaly, karyomegaly and anisokaryosis occurred in male and female rats and female mice receiving 2 38 mg kg-' EXPERIMENTAL Chemical Hexachlorocyclopentadiene (97.4%) was obtained from Velsicol Chemical Corporation, Chicago, 11. The impurities were tetrachloroethylene (0.1 5 f O.Ol%), hexachloro-l,3butadiene ( O S 1 * O.Ol%), octachlorocyclopentene (1.73 k 0.07%) and hexachloro -3 -cyclopentene-1-one (0.48 f 0.02%).