No evidence of toxicity or carcinogenicity of pentaerythritol tetranitrate given in the diet to F344 rats and B6C3F1 mice for up to two years
✍ Scribed by John R. Bucher; James Huff; Joseph K. Haseman; Scot L. Eustis; Herman S. Lilja; A. S. K. Murthy
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 515 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0260-437X
No coin nor oath required. For personal study only.
✦ Synopsis
Toxicology and carcinogenesis studies of pentaerythritol tetranitrate (PETN), an organic nitrate used in explosives and as a therapeutic agent for angina pectoris, were conducted by administering diets containing PETN,NF (National Formulary Grade, a 1:4 mixture of PETN and lactose) to both sexes of F344 rats and B6C3F1 mice in 14-day, 13-week and 2-year studies. PETN was found to be essentially non-toxic in 14-day and 13-week studies at dietary concentrations as high as 10 000 ppm; the weight gain of female rats was lower than that of controls at 5000 and 10 000 ppm in the 13-week study. In the 13-week studies, one in ten highdose female rats had an adenoma of the Zymbal gland and one in ten high-dose female mice had a hepatocellular adenoma. Dietary concentrations chosen for the 2-year studies were 5000 and 10 000 ppm for male rats and male and female mice, and 1240 and 2500 ppm for female rats. In the 2-year studies, there were no adverse effects on survival or body weight gains in either sex of rats or mice. No neoplastic or non-neoplastic lesions were considered to be related clearly to PETN administration. Neoplasms of the Zymbal gland occurred at low incidences in PETN-exposed groups of both sexes of rats in the 2-year study.