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Toxic Effects of Acute Glutathione Depletion by Buthionine Sulfoximine and Dimethylfumarate on Murine Mammary Carcinoma Cells

✍ Scribed by L. A. Dethlefsen, C. M. Lehman, J. E. Biaglow and V. M. Peck

Book ID
124656671
Publisher
Bioone
Year
1988
Tongue
English
Weight
911 KB
Volume
114
Category
Article
ISSN
0033-7587

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Cytotoxic effects of glutathione synthesis inhibition by L-buthionine-(SR)-sulfoximine on human and murine tumor cells
✍ Robert T. Dorr; James D. Liddil; Michelle J. Soble πŸ“‚ Article πŸ“… 1986 πŸ› Springer US 🌐 English βš– 601 KB

The glutathione (GSH) synthesis inhibitor, buthionine sulfoximine (BSO) was tested for cytotoxicity and thiol depletion in murine and human tumor cells in vitro, and for its antitumor activity and toxicity in vivo. The cell lines used in these studies included murine L-1210 leukemia, human RPMI 8226