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Towards an evidence-based process for the clinical interpretation of copy number variation

✍ Scribed by ER Riggs; DM Church; K Hanson; VL Horner; EB Kaminsky; RM Kuhn; KE Wain; ES Williams; S Aradhya; HM Kearney; DH Ledbetter; ST South; EC Thorland; CL Martin

Book ID
115091982
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
666 KB
Volume
81
Category
Article
ISSN
0009-9163

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Evidence for variation in the number of
Evidence for variation in the number of functional gene copies at the AmaR locus in chinese hamster cell lines
✍ Radhey S. Gupta; David Y. H. Chan; Louis Siminovitch πŸ“‚ Article πŸ“… 1978 πŸ› John Wiley and Sons 🌐 English βš– 524 KB

## Abstract The hypothesis of functional hemizygosity has been examined for the α‐amanitin resistant (Ama^R^, a codominant marker) locus in a series of Chinese hamster cell lines. Ama^R^ mutants were obtained from different cell lines, e.g., CHO, CHW, M3‐1 and CHO‐Kl, at similar frequencies. After