𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Towards an asymmetric synthesis of ADDA conjugates

✍ Scribed by Darren J. Cundy; Andrew C. Donohue; Tom D. McCarthy

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
337 KB
Volume
39
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

In order to develop a general synthesis of ADDA containing peptides, an asymmetric synthesis of the p-lactam 4 and initial investigations into its opening with aminoesters is described.

📜 SIMILAR VOLUMES

ChemInform Abstract: Towards an Asymmetr
ChemInform Abstract: Towards an Asymmetric Synthesis of ADDA Conjugates.
✍ D. J. CUNDY; A. C. DONOHUE; T. D. MCCARTHY 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

Towards an Asymmetric Synthesis of ADDA Conjugates. -In order to develop a general synthesis of ADDA-containing peptides the synthesis of lactam (VII) via a optimized coupling of the aldehyde (II) with the sulfone (III) is detailed. Furthermore, initial investigations concerning ring opening of (VII

Synthesis of peptide-diazeniumdiolate co
Synthesis of peptide-diazeniumdiolate conjugates: towards enzyme activated antitumor agents
✍ Xiaoping Tang; Ming Xian; Mohit Trikha; Kenneth V Honn; Peng George Wang 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 130 KB

The development of NO donors with site-specific and time-controlled properties is of great interest. We have designed a novel prodrug class as possible agents against metastatic prostate cancer by coupling a diazeniumdiolate to the terminal carboxyl groups of amino acids or peptides, such as Ser-Ser

An asymmetric nickel–chromium coupling t
An asymmetric nickel–chromium coupling toward the synthesis of Baylis–Hillman adducts
✍ Francis G. Fang; Thomas E. Horstmann; Jonathan Therrien 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 341 KB

An asymmetric nickel-chromium coupling strategy has been employed in the generation of enantioenriched Baylis-Hillman adducts with selectivities reaching >90% ee and in fair to moderate yields (up to 65%) using a chiral sulfonamide ligand. The reaction conditions appear to show reasonable generality