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ChemInform Abstract: Towards an Asymmetric Synthesis of ADDA Conjugates.

✍ Scribed by D. J. CUNDY; A. C. DONOHUE; T. D. MCCARTHY

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Towards an Asymmetric Synthesis of ADDA Conjugates. -In order to develop a general synthesis of ADDA-containing peptides the synthesis of lactam (VII) via a optimized coupling of the aldehyde (II) with the sulfone (III) is detailed. Furthermore, initial investigations concerning ring opening of (VII) with the aminoester (VIII) are described. -(CUNDY, D.

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