✦ LIBER ✦

Synthesis of peptide-diazeniumdiolate conjugates: towards enzyme activated antitumor agents

✍ Scribed by Xiaoping Tang; Ming Xian; Mohit Trikha; Kenneth V Honn; Peng George Wang

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 130 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)00263-5

No coin nor oath required. For personal study only.

✦ Synopsis

The development of NO donors with site-specific and time-controlled properties is of great interest. We have designed a novel prodrug class as possible agents against metastatic prostate cancer by coupling a diazeniumdiolate to the terminal carboxyl groups of amino acids or peptides, such as Ser-Ser-Tyr-Tyr, Ser-Ser-Phe-Tyr, and Gly-Ile-Ser-Ser-Phe-Tyr. These prodrugs can be activated by a-chymotrypsin or prostate specific antigen and are potentially potent compounds for prostatic cancer.

📜 SIMILAR VOLUMES

ChemInform Abstract: Synthesis of Peptid

ChemInform Abstract: Synthesis of Peptide-Diazeniumdiolate Conjugates: Towards Enzyme Activated Antitumor Agents.

✍ Xiaoping Tang; Ming Xian; Mohit Trikha; Kenneth V. Honn; Peng George Wang 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v