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Towards Allosteric Receptors – Synthesis of Resorcinarene-Functionalized 2,2′-Bipyridines and Their Metal Complexes

✍ Scribed by Holger Staats; Friederike Eggers; Oliver Haß; Frank Fahrenkrug; Jens Matthey; Ulrich Lüning; Arne Lützen

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
500 KB
Volume
2009
Category
Article
ISSN
1434-193X

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✦ Synopsis

Abstract

Based on a first example of an allosteric hemicarcerand (1) we prepared four new 2,2′‐bipyridines that carry resorcinarene moieties in a highly convergent manner. Upon coordination to suitable transition metal ions or their complexes these compounds undergo conformational changes in a way that they switch between “open” and “closed” forms (2, 3, and 4) or vice versa (5), thus, bringing together or separating the two functional moieties on the central bipyridine. Among the transition metal complexes that act as effectors for the conformational switching, [Re(CO)~5~Cl] and monomeric copper(I) complexes of sterically hindered 2,9‐arylated 1,10‐phenanthrolines proved to be very effective. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

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