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Synthesis of 2-Amino-3-heteroaroylthiophenes and Evaluation of Their Activity as Potential Allosteric Enhancers at the Human A1 Receptor.

✍ Scribed by Pier Giovanni Baraldi; Maria Giovanna Pavani; John C. Shryock; Allan R. Moorman; Valeria Iannotta; Pier Andrea Borea; Romeo Romagnoli

Publisher: John Wiley and Sons
Year: 2005
Weight: 16 KB
Volume: 36
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200511127

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✦ Synopsis

Thiophene derivatives R 0090

Synthesis of 2-Amino-3-heteroaroylthiophenes and Evaluation of Their Activity as Potential Allosteric Enhancers at the Human A1 Receptor. -The synthesis of a series of title compounds (III) by a known procedure is reported. The effect of substituents at positions 4 and 5 of the thiophene ring on enhancer activity and the ability of the new substances to reduce the cAMP content in CHO cells expressing the human adenosine A 1 receptor are evaluated. -(BARALDI*, P. G.; PAVANI, M. G.;

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