Synthesis and Structure—Activity Relationships of (R)-1-Alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as Human GnRH Receptor Antagonists.
✍ Scribed by Martin W. Rowbottom; Fabio C. Tucci; Yun-Fei Zhu; Zhiqiang Guo; Timothy D. Gross; Greg J. Reinhart; Qui Xie; R. Scott Struthers; John Saunders; Chen Chen
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 102 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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Novel analogs of the P2 receptor antagonist pyridoxal-5′-phosphate-6-phenylazo-2′,4′disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the inclusion of phosphonates, demonstrating that a phos