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Towards a structure-function analysis of bovine lactoferricin and related tryptophan- and arginine-containing peptides

✍ Scribed by Vogel, Hans J; Schibli, David J; Jing, Weiguo; Lohmeier-Vogel, Elke M; Epand, Raquel F; Epand, Richard M

Book ID
119962959
Publisher
NRC Research Press
Year
2002
Tongue
English
Weight
1014 KB
Volume
80
Category
Article
ISSN
0829-8211

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✍ Bengt Erik Haug; Jill Andersen; Øystein Rekdal; Dr John S. Svendsen 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 99 KB

## Abstract A modified tryptophan, β‐[2‐(2,2,5,7,8‐pentamethylchroman‐6‐sulphonyl)‐indol‐3‐yl]alanine, Trp(2 − Pmc) = Tpc has been synthesized. Replacement of tryptophan in a bovine lactoferricin model peptide with the modified tryptophan resulted in peptides with a substantially increased antibact