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Toward the Total Synthesis of Spirastrellolide A. Part 3. Intelligence Gathering and Preparation of a Ring-Expanded Analogue (II).

✍ Scribed by Alois Fuerstner; Bernhard Fasching; Gregory W. O'Neil; Michael D. B. Fenster; Cedrickx Godbout; Julien Ceccon


Book ID
102010434
Publisher
John Wiley and Sons
Year
2007
Weight
21 KB
Volume
38
Category
Article
ISSN
0931-7597

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Toward the Total Synthesis of Spirastrel
✍ Alois Fürstner; Michaël D. B. Fenster; Bernhard Fasching; Cédrickx Godbout; Kari 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 240 KB 👁 2 views

The novel antimitotic agent spirastrellolide A (1), isolated from the Caribbean sponge Spirastrella coccinea, is endowed with potent and selective phosphatase inhibitory properties. [1] Although the relative stereochemistry of each individual domain embedded into the macrocyclic frame of this marine