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Titelbild: Toward the Total Synthesis of Spirastrellolide A. Part 1: Strategic Considerations and Preparation of the Southern Domain / Toward the Total Synthesis of Spirastrellolide A. Part 2: Conquest of the Northern Hemisphere (Angew. Chem. 33/2006)

✍ Scribed by Alois Fürstner; Michaël D. B. Fenster; Bernhard Fasching; Cédrickx Godbout; Karin Radkowski


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
134 KB
Volume
118
Category
Article
ISSN
0044-8249

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Toward the Total Synthesis of Spirastrel
✍ Alois Fürstner; Michaël D. B. Fenster; Bernhard Fasching; Cédrickx Godbout; Kari 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 240 KB 👁 2 views

The novel antimitotic agent spirastrellolide A (1), isolated from the Caribbean sponge Spirastrella coccinea, is endowed with potent and selective phosphatase inhibitory properties. [1] Although the relative stereochemistry of each individual domain embedded into the macrocyclic frame of this marine