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Toward the Total Synthesis of Spirastrellolide A. Part 2. Conquest of the Northern Hemisphere (I).

✍ Scribed by Alois Fuerstner; Michael D. B. Fenster; Bernhard Fasching; Cedrickx Godbout; Karin Radkowski


Publisher
John Wiley and Sons
Year
2006
Weight
11 KB
Volume
37
Category
Article
ISSN
0931-7597

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Toward the Total Synthesis of Spirastrel
✍ Alois Fürstner; Michaël D. B. Fenster; Bernhard Fasching; Cédrickx Godbout; Kari 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 240 KB 👁 2 views

The novel antimitotic agent spirastrellolide A (1), isolated from the Caribbean sponge Spirastrella coccinea, is endowed with potent and selective phosphatase inhibitory properties. [1] Although the relative stereochemistry of each individual domain embedded into the macrocyclic frame of this marine