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Toward the Elucidation of the Catalytic Mechanism of the Mono-ADP-Ribosyltransferase Activity of Pseudomonas aeruginosa Exotoxin A †

✍ Scribed by Armstrong, Souzan; Merrill, A. Rod


Book ID
126186883
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
229 KB
Volume
43
Category
Article
ISSN
0006-2960

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Pseudomonas aeruginosa exotoxin A is a representative of a class of enzymes, the mono-ADP-ribosyl transferases, which catalyze the covalent transfer of an ADP-ribose moiety of NAD+ to a target substrate. Availability of the three-dimensional structure of exotoxin A provides the opportunity for mappi