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Characterization of Competitive Inhibitors for the Transferase Activity of Pseudomonas aeruginosa Exotoxin A

โœ Scribed by Armstrong, Souzan; Li, Jia-He; Zhang, Jie; Rod Merrill, A.


Book ID
115507852
Publisher
Informa plc
Year
2002
Tongue
English
Weight
386 KB
Volume
17
Category
Article
ISSN
1475-6366

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Pseudomonas aeruginosa exotoxin A is a representative of a class of enzymes, the mono-ADP-ribosyl transferases, which catalyze the covalent transfer of an ADP-ribose moiety of NAD+ to a target substrate. Availability of the three-dimensional structure of exotoxin A provides the opportunity for mappi