Totalsynthese von Thymosin β4, 1. Klassische Synthese des Fragments [11–19] von Thymosin β4

✍ Scribed by Kapurniotu, Afroditi ;Voelter, Wolfgang

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 822 KB
• Volume: 1991
• Category: Article
• ISSN: 0947-3440
• DOI: 10.1002/jlac.1991199101216

✦ Synopsis

Total Synthesis of Thymosin β~4~, 1. – Conventional Synthesis of the Fragment [11–19] of Thymosin β~4~

As part of the total synthesis of thymosin β~4~ two synthetic pathways for the synthesis of the thymosin β~4~ fragment [11–19] are described. The side‐chain functions are protected by tert‐butyl and the α‐amino residues by Z groups. As temporary protection of the carboxyl function the phenyl ester is successfully used.