Enantioselective formal total synthesis
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Frederick Calo; Jeffery Richardson; Andrew J.P. White; Anthony G.M. Barrett
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Article
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2009
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Elsevier Science
🌐
French
⚖ 428 KB
An enantioselective formal total synthesis of (À)-trachyspic acid was carried out using, as key steps, an asymmetric aldol reaction of a chiral oxazolidinone and a diastereoselective alkylation of a chiral 1,3dioxolan-2-one. The key lactone 3 was synthesized in five steps starting from dioxolanone 9