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Enantioselective formal total synthesis of (−)-trachyspic acid

✍ Scribed by Frederick Calo; Jeffery Richardson; Andrew J.P. White; Anthony G.M. Barrett

Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
428 KB
Volume
50
Category
Article
ISSN
0040-4039

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✦ Synopsis

An enantioselective formal total synthesis of (À)-trachyspic acid was carried out using, as key steps, an asymmetric aldol reaction of a chiral oxazolidinone and a diastereoselective alkylation of a chiral 1,3dioxolan-2-one. The key lactone 3 was synthesized in five steps starting from dioxolanone 9.

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Asymmetric synthesis of (+)-trachyspic a
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