Total Synthesis of Theopederin D
✍ Scribed by Michael E. Green; Jason C. Rech; Paul E. Floreancig
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 334 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
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A Synthesis of Theopederin D and a Formal Synthesis of Pederin. -The first synthesis of theopederin D (IV), a cytotoxic metabolite from a marine sponge, based on the coupling of two advanced intermediates (I) and (II) is described. Moreover, an improved synthesis of the amide (VIII), a key intermed
An Enantioselective Total Synthesis of (+)-Methyl Pederate. -The key intermediate for theopederins, methyl pederate (IV), is available by a practical route involving the pivotal Pd-catalyzed cyclization of the carbonate (II) as key step. -(TOYOTA, M.;