Total synthesis of the polyenoyltetramic acid polycephalin C

✍ Scribed by Deborah A Longbottom; Angus J Morrison; Darren J Dixon; Steven V Ley

• Book ID: 104205467
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 325 KB
• Volume: 59
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(03)00816-0

✦ Synopsis

The total synthesis of the polyenoyltetramic acid polycephalin C is described. Key steps of the synthesis include a double Swern oxidation, double Takai reaction and a double Stille reaction. In addition, the absolute stereochemistry of the ring junction has been determined by synthesis of both isomers and comparison of their CD spectra with natural polycephalin C.