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Total Synthesis of the Novel, Immunosuppressive Agent (−)-Pateamine A from Mycale sp. Employing a β-Lactam-Based Macrocyclization

✍ Scribed by Rzasa, Robert M.; Shea, Helene A.; Romo, Daniel


Book ID
120650506
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
45 KB
Volume
120
Category
Article
ISSN
0002-7863

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ChemInform Abstract: Total Synthesis of
✍ Daniel Romo; Robert M. Rzasa; Helene A. Shea; Kaapjoo Park; Joseph M. Langenhan; 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 43 KB 👁 2 views

Total Synthesis of Immunosuppressive Activity of (-)-Pateamine A and Related Compounds: Implementation of a β-Lactam-Based Macrocyclization. -The key step of the convergent, stereoflexible route to pateamine A (X) and derivatives is based on the macrocyclization of β-lactam (IV). The use of NEt 4 C