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ChemInform Abstract: Total Synthesis of the Novel, Immunosuppressive Agent (-)-Pateamine A from Mycale sp. Employing a β-Lactam-Based Macrocyclization.

✍ Scribed by R. M. RZASA; H. A. SHEA; D. ROMO


Publisher
John Wiley and Sons
Year
2010
Weight
44 KB
Volume
29
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Total Synthesis of
✍ Daniel Romo; Robert M. Rzasa; Helene A. Shea; Kaapjoo Park; Joseph M. Langenhan; 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 43 KB 👁 1 views

Total Synthesis of Immunosuppressive Activity of (-)-Pateamine A and Related Compounds: Implementation of a β-Lactam-Based Macrocyclization. -The key step of the convergent, stereoflexible route to pateamine A (X) and derivatives is based on the macrocyclization of β-lactam (IV). The use of NEt 4 C