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Total Synthesis and Immunosuppressive Activity of (−)-Pateamine A and Related Compounds: Implementation of a β-Lactam-Based Macrocyclization

✍ Scribed by Romo, Daniel; Rzasa, Robert M.; Shea, Helene A.; Park, Kaapjoo; Langenhan, Joseph M.; Sun, Luo; Akhiezer, Alexander; Liu, Jun O.

Book ID
118189138
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
705 KB
Volume
120
Category
Article
ISSN
0002-7863

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ChemInform Abstract: Total Synthesis of
ChemInform Abstract: Total Synthesis of Immunosuppressive Activity of (-)-Pateamine A and Related Compounds: Implementation of a β-Lactam-Based Macrocyclization.
✍ Daniel Romo; Robert M. Rzasa; Helene A. Shea; Kaapjoo Park; Joseph M. Langenhan; 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 43 KB 👁 2 views

Total Synthesis of Immunosuppressive Activity of (-)-Pateamine A and Related Compounds: Implementation of a β-Lactam-Based Macrocyclization. -The key step of the convergent, stereoflexible route to pateamine A (X) and derivatives is based on the macrocyclization of β-lactam (IV). The use of NEt 4 C