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Total synthesis of the novel angiogenesis inhibitors epoxyquinols A and B

✍ Scribed by Goverdhan Mehta; Kabirul Islam

Book ID: 104253426
Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 451 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00621-x

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✦ Synopsis

The synthesis of the recently discovered angiogenesis inhibitors epoxyquinols A and B, having novel polyketide derived dimeric structures, has been accomplished from the readily available Diels-Alder adduct of cyclopentadiene and p-benzoquinone through a short, simple and flexible strategy that is diversity oriented and can be adapted to an asymmetric variant.

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