Total synthesis of the marine pyridoacridine alkaloid sebastianine A

✍ Scribed by Laurent Legentil; Jean Bastide; Evelyne Delfourne

• Book ID: 104253207
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 81 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)00320-4

✦ Synopsis

The synthesis of the marine alkaloid sebastianine A and of a regioisomer has been accomplished via hetero-Diels-Alder reaction of indole-4,7-dione or N-tosylindole-4,7-dione with trifluoroacetamidocinnamaldehyde dimethylhydrazone, and subsequent cyclisation in alkaline conditions.