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Total synthesis of the cytotoxic Annonaceous acetogenin (30S)-bullanin

✍ Scribed by James A. Marshall; Kevin W. Hinkle

Book ID
104258617
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
284 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

The total synthesis of (+)-(30s)bullanin, a highly cytotoxic Annonaceous acetogenin, was effected by a convergent approach in which the key core his-2,2'-tetrahydrofuran stereocenters were introduced through a combination of Sharpless asymmetric dihydroxylation and S,2' additions of oxygenated nonracemic allylic stannane and indium reagents to y-oxygenated aldehydes.

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