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Total Synthesis of the Cytotoxic Threo , Trans , Erythro , Cis , Threo Annonaceous Acetogenin Trilobin

โœ Scribed by Marshall, James A.; Jiang, Hongjian


Book ID
126261882
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
148 KB
Volume
64
Category
Article
ISSN
0022-3263

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Total synthesis of the cytotoxic Annonac
โœ James A. Marshall; Kevin W. Hinkle ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 284 KB

The total synthesis of (+)-(30s)bullanin, a highly cytotoxic Annonaceous acetogenin, was effected by a convergent approach in which the key core his-2,2'-tetrahydrofuran stereocenters were introduced through a combination of Sharpless asymmetric dihydroxylation and S,2' additions of oxygenated nonra