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Total Synthesis of the CP Molecules CP-263,114 and CP-225,917— Part 1: Synthesis of Key Intermediates and Intelligence Gathering

✍ Scribed by K. C. Nicolaou; Phil S. Baran; Yong-Li Zhong; Ha-Soon Choi; Won Hyung Yoon; Yun He; Kin Chiu Fong

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
186 KB
Volume
38
Category
Article
ISSN
0044-8249

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The Absolute Configuration and Asymmetri
The Absolute Configuration and Asymmetric Total Synthesis of the CP Molecules (CP-263,114 and CP-225,917, Phomoidrides B and A)
✍ K. C. Nicolaou; Jae-Kyu Jung; Won Hyung Yoon; Yun He; Yong-Li Zhong; Phil S. Bar 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 104 KB

The stunning molecular structures [1] coupled with the promising biological activities of the CP compounds (pho-moidrides, [2] 1 a and b; Figure 1) have inspired numerous studies directed at their total synthesis. [3] In 1999 we reported the first total synthesis of these molecules in their racemic