The Absolute Configuration and Asymmetric Total Synthesis of the CP Molecules (CP-263,114 and CP-225,917, Phomoidrides B and A)

✍ Scribed by K. C. Nicolaou; Jae-Kyu Jung; Won Hyung Yoon; Yun He; Yong-Li Zhong; Phil S. Baran

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 104 KB
• Volume: 112
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/(sici)1521-3757(20000515)112:10<1899::aid-ange1899>3.0.co;2-v

✦ Synopsis

The stunning molecular structures [1] coupled with the promising biological activities of the CP compounds (pho-moidrides, [2] 1 a and b; Figure 1) have inspired numerous studies directed at their total synthesis. [3] In 1999 we reported the first total synthesis of these molecules in their racemic form. [4] Their absolute configuration, however, remained unknown despite the many attempts to prepare and analyze, through X-ray crystallography, a suitably crystalline derivative. After securing the overall structure and configuration at COOH