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Total synthesis of (±)-rhopaloic acid A

✍ Scribed by Barry B. Snider; Feng He

Book ID
104257575
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
147 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

A six-step synthesis of rhopaloic acid A (1E) was accomplished in 25% overall yield using the Pd(II)mediated cyclization and methoxycarbonylation of allenyl alcohol 3, which affords 83% of a 6:1 mixture of tetrahydropyranylacrylates 2 and 8, as the key step.

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