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ChemInform Abstract: Asymmetric Synthesis of Rhopaloic Acid A Analogues and Their Biological Properties.

✍ Scribed by Hiroko Nishitani; Asami Sasaoka; Munetaka Tokumasu; Katsuo Ohkata

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Asymmetric Synthesis of Rhopaloic Acid A Analogues and Their Biological Properties.

-In order to study structure-activity relationships of cytotoxic rhopaloic acid, related analogues such as (X) are synthesized. The routes are based on asymmetric alkylation of a chiral oxazolidine (I) and construction of the tetrahydropyran moiety by way of malonic ester synthesis. Compared to rhopaloic acid, the analogues which bear a shorter isoprenoid side chain exhibit decreased activity. -(NISHITANI, HIROKO; SASAOKA,

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