ChemInform Abstract: Synthesis and Biological Property of Carba and 20-Deoxo Analogues of Arenastatin A.
β Scribed by Nobutoshi Murakami; Weiqi Wang; Satoru Tamura; Motomasa Kobayashi
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 28 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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Asymmetric Synthesis of Rhopaloic Acid A Analogues and Their Biological Properties. -In order to study structure-activity relationships of cytotoxic rhopaloic acid, related analogues such as (X) are synthesized. The routes are based on asymmetric alkylation of a chiral oxazolidine (I) and construct